Agglutination Reactions of Artemisinin-Type Drugs and Other Substances

نویسندگان

چکیده

Artemisinin is a good antimalarial drug independently developed in China. It highly effective and low toxic. In the process of studying mechanism artemisinin drugs, we found that there was agglutination when drugs came into contact with blood. Methods: ABO positive typing test card used to detect reaction dihydroartemisinic whole blood, red blood cells, hemolytic solution, hemin chloride, ferrous sulfate, ferric sodium DMSO artemether. Results: can agglutinate many substances, such as cell chloride so on. The this paper not related antigen antibody, but result interaction between various substances. Whole cells fluid contain biological macromolecular components. Hemin belongs molecular organic compounds, rest are simple inorganic compounds. interact wide range substances agglutinate, indicating their strong effect. clear. speculated it “oxygen bridge” molecule, details action how need be studied. Interestingly, artemether interacts dihydroartemisinin, no agglutination, tendency control, which contrary other results. This phenomenon, interaction, its significance further

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ژورنال

عنوان ژورنال: BIO web of conferences

سال: 2023

ISSN: ['2273-1709', '2117-4458']

DOI: https://doi.org/10.1051/bioconf/20236001006